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Pashanbheda
(Coleus forskohlii)

English Name: 

Family: Saxifragaceae.

kidney stones, bladder infection, water retention, fever, chronic ulcers, skin wounds, diarrhea.

In ayurvedic practice, Pashanabheda, as its name suggests, is used as a litholytic agent for urinary calculi. It is widely. The alcoholic extract displays marked anti-bradykinin activity although it does not affect the action of 5-HT and acetylcholine on isolated guinea pig ileum. It has been shown to potentiate the action of adrenaline on guinea-pig trachea and ileal muscle. 

The alcoholic extract.has a marked anti-inflammatory effect on the response to various forms of experimental injury. The anti-inflammatory effect of the extract, like its diuretic effect, is reduced when higher doses of the drug are employed. There is also a mention of antiviral activity against influenza-A virus.sed in the treatment of dysuria and renal failure, cystitis and crystalluria. Its anti-inflammatory property finds a use in the treatment of abscesses and cutaneous infections. It is also used in the treatment of dysentery and diarrhoea.

Treatment of a chronic bronchitis. The antilithic property of the crude extract has been investigated by several workers. Low doses of Pashanabheda extract (0.5 mg/kg of alcoholic extract) promote diuresis in rats, but higher doses 100 mg/kg reduce the urine output, and also reduce the diuresis produced by urea. In rats, the extract reduced spontaneous motor activity and besides its own analgesic action it also potentiated morphine analgesia. However, it had no protective effect against convulsions produced by pentylene tetrazol or electric shock. There is significant CNS depressant activity in the crude extract .